Taro Kawai

河合 太郎|Taro Kawai

大阪大学研究者総覧

業績

主な論文

Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T.
NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections. J Immunol. 2010 Dec 8. [Epub ahead of print]
Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S. The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA. Immunity. 2010 Nov 10. [Epub ahead of print]
Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T. Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan J Immunol 2009 Dec 15;183(12):8061-8067.
Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. J Immunol. 2008 Jan 15;180(2):683-687.
Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med. 2006 Jul 10;203(7):1795-1803.
* contributed equally
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S, Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses. J Immunol. 2006 Apr 15;176(8):4520-4524.
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction Nat Immunol. 2005, Oct;6(10):981-988.
Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S. Interferon-a induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-1068.
Kawai T, Akira S, Reed JC. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol. 2003 Sep;23(17):6174-6186.
Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, Hoshino K, Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol. 2001 Nov 15;167(10):5887-5894.
Nomura F*, Kawai T*, Nakanishi K, Akira S. NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. Genes Cells. 2000 Mar;5(3):191-202.
* contributed equally
Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 1999 Jul;11(1):115-122.
Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene. 1999 Jun 10;18(23):3471-3480.
Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol. 1998 Mar;18(3):1642-1651.

英文総説

Kawai T, Akira S. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity. 2011 May 27;34(5):637-50.
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010 May;11(5):373-84.
Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol. 2009 Apr;21(4):317-37.
Kawai T, Akira S, Toll-like Receptor and RIG-1-like Receptor signaling. Ann N Y Acad Sci. 2008 Nov;1143:1-20.
Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007 Nov;13(11):460-9.
Kawai T, Akira S. SnapShot: Pattern-Recognition Receptors. Cell. 2007 Jun 1;129(5):1024.
Kawai T, Akira S. TLR signaling. Semin Immunol. 2007 Feb;19(1):24-32.
Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem (Tokyo). 2007 Feb;141(2):137-45.
Kawai T, Akira S, TLR-signaling. Cell Death Differ. 2006 May;13(5):816-825.
Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006 Feb;7(2):131-137.
Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005, 17(4):338-344.
Kawai T, Akira S. Toll-like receptor downstream signaling. Arthritis Res. 2005, 7:12-19

受賞・表彰

2007
2nd Japanese Society for Immunology Young Investigator Award (Nov 2007)
2004
Poster Award, 13th International Symposium on Molecular Cell Biology of Macrophages 2004 (July 2004, Osaka, Japan)
2001
Tobacco-Related Disease Research Program (TRDRP) Postdoctoral Fellowship Award (2001-2003)

そのほか

2007
New Hot Paper Comments, Thomson Essential Science Indicators special TOPICS (March 2007)
2006
New Hot Paper Comments, Thomson Essential Science Indicators special TOPICS (January 2006)