shizuo akira

審良 静男|Shizuo Akira

大阪大学研究者総覧
Researcher ID
研究室ホームページ

学歴

1977
大阪大学医学部卒業
1984
大阪大学医学研究科博士課程修了

職歴

1978
堺市立病院内科医師
1984
日本学術振興会奨励研究員
1985
カリフォルニア大学バークレー校博士研究員
1987
大阪大学細胞工学センター助手(免疫研究部門)
1995
大阪大学細胞生体工学センター助教授
1996
兵庫医科大学生化学教授
2005
大阪大学微生物病研究所自然免疫学分野教授
2007
大阪大学免疫学フロンティア研究センター拠点長

業績

最近の主な論文

Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S.
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Nature. 2013. in press
Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Nat. Immunol. 2013. in press
Saitoh T, Komano J, Saitoh Y. Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoyo N, Akira S.
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
Cell Host Microbe. 12(1):109-16, 2012
Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O.
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
J Biol Chem. 287(34):29114-24, 2012
Kond T, Kawai T, Akira S.
Dissecting negative regulation of Toll-like receptor signaling.
Trends Immunol. 33(9):449-58, 2012
Teraguchi S, Kumagai Y, Vandenbon A, Akira S, Standley DM.
Stochastic binary modeling of cells in continuous time as an alternative to biodhemical reaction equations.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec; 84(6 Pt 1):062903
Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Nat Immunol. 2011 Oct 30; 12(12):1167-1175
Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S.
A New Subset of CD103+CD8{alpha}+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity.
J Immunol. 2011 Jun 1;186(11):6287-6295
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells.
Immunity. 2011 Mar 25;34(3):352-63.
Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T.
NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections.
J Immunol. 2011 Jan 15;186(2):994-1000
Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA.
Immunity. 2010 Nov 24;33(5):765-776
Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.
I{kappa}B{zeta} is essential for natural killer cell activation in response to IL-12 and IL-18.
Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17680-17685
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.
Nat Immunol. 2010 Oct 11; 11(10):936-944.
Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nuñez G, Ishii KJ, Akira S.
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.
Cell Host Microbe. 7(1):50-61, 2010
Kawai T., Akira S.
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Nat Immunol, 11(5), 373-384, 2010.
Takeuchi O., Akira S.
Pattern recognition receptors and inflammation.
Cell. 140(6), 805-820, 2010.
Satoh T., Kato H., Kumagai Y., Yoneyama M., Sato S., Matsushita K., Tsujimura T., Fujita T., Akira S., Takeuchi O.
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Proc Natl Acad Sci U S A, 107(4), 1512-7, 2010.

受賞・表彰

2000
井上学術賞
2001
野口英世記念医学賞
2002
大阪科学賞
2003
武田医学賞
2004
高松宮妃癌研究基金学術賞
2004
ロベルト・コッホ賞(Robert Koch Prize)
2005
紫綬褒章
2006
朝日賞
2006
コーリー賞(Wilddam B Culey Award)
2007
Thompson Scientific Research Award 2007
2007
上原賞
2007
学士院賞・恩賜賞
2007
ミルシュタイン賞(Milstein Award)
2009
米国科学アカデミー(NAS)外国人会員
2009
文化功労者
2010
アベリー・ランドスタイナー賞
2010
慶應医学賞
2011
ガードナー国際賞

そのほか

2003-2004
"Hottest Researchers"第8位(トムソン社による調査)
2004-2005
"Hottest Researchers"第1位
2005-2006
"Hottest Researchers"第1位
2006-2007
"Hottest Researchers"第4位
2007
ミュンヘン工科大学名誉医学博士
2007
Harvard大学でDunham lecture
2008
National Institutes of HealthでDyer lecture
過去10年間での発表論文の総引用回数、2004年以降免疫学分野で第1位(トムソン社による調査)