osamu takeuchi

竹内 理|Osamu Takeuchi



大阪大学医学研究科博士課程 修了





Miyake T, Satoh T, Kato H, Matsushita K, Kumagai T, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O.I{kappa}B{zeta} is essential for natural killer cell activation in response to IL-12 and IL-18.Proc Natl Acad Sci U S A. 2010 Sep 27, [Epub ahead of print]
Satoh T*, Takeuchi O*, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S. (*equal contribution) The JMJD3-IRF4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010 Aug 22. [Epub ahead of print]
Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7.
Kawagoe T*, Takeuchi O*, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S (*equal contribution) TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol. 2009 Sep;10(9):965-72.
Matsushita K*, Takeuchi O*, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S (*equal contribution) Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 2009 458: 1185-90
Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med. 2008 14:86-92
Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat. Immunol. 2008 9:684-91
Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira, S. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 2007 27:240-52.
Kato H*, Takeuchi O*, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S (*equal contribution). Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 441:101-5.
Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 102:11272-7.
Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S. Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity. 2005 23:19-28.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999, 11:443-51


Takeuchi O, Akira S. Pattern Recognition Receptors and Inflammation. Cell. 2010 Mar 19;140(6):805-820.
Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev. 2009 Jan;227(1):75-86.
Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol. 2008 20:17-22.
Takeuchi O, Akira S. Signaling pathways activated by microorganisms. Curr Opin Cell Biol. 2007 Apr;19(2):185-91.
Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006 Feb 24;124(4):783-801
Takeuchi O, Hemmi H, Akira S. Interferon response induced by Toll-like receptor signaling. J Endotoxin Res. 2004;10(4):252-256.
Takeuchi O, Akira S. MyD88 as a bottle neck in Toll/IL-1 signaling. Curr Top Microbiol Immunol. 2002;270:155-67.
Takeuchi O, Akira S. Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol. 2001 Apr;1(4):625-35.


Takeuchi O, Akira S. The Biology of Toll-like receptors in Mice, The Mouse in Biomedical Research Second Edition, Elsevier 2006
Takeuchi O, Akira S. Toll-like receptor signaling, Dendritic cell interactions with bacteria. Series: Advances in Molecular and Cellular Microbiology, Cambridge University Press. 2006
Takeuchi O, Akira S. Innate Immunity, Encyclopedia of Molecular Cell Biology and Molecular Medicine Second Edition. Wiley -VCH 2005


Yamamura Award
3rd Japanese Society for Immunology Young Investigator Award


Human Frontier Science Program Long-term fellow (2002-2004)