kazuya suzuki

菊地 和也|Kazuya Kikuchi

研究者総覧
Researcher ID
研究室ホームページ

学歴

1984
東京大学教養学部理科II類入学
1986
東京大学薬学部進学
1988
東京大学薬学部卒業
1988
東京大学大学院薬学系研究科修士課程入学
1990
東京大学大学院薬学系研究科修士課程卒業

職歴

1990
(株)武田薬品工業入社
1990
(株)武田薬品工業退職
1990
東京大学大学院薬学系研究科大学院研究生
1991
東京大学大学院薬学系研究科博士課程入学
1994
東京大学大学院薬学系研究科博士課程卒業
1994
日本学術振興会博士特別研究員
1994
カリフォルニア大学サンディエゴ校博士研究員(化学及び生化学科・薬理学科Roger Y. Tsien教授)
1995
スクリプス研究所博士研究員(化学科Donald Hilvert教授)
1997
東京大学大学院薬学系研究科助手
2000
東京大学大学院薬学系研究科助教授
2001
科学技術振興事業団「さきがけ研究21」「タイムシグナルと制御」研究領域 研究員(兼任)
2005
大阪大学大学院工学研究科生命先端工学専攻教授
2009
大阪大学免疫学フロンティア研究センター教授(兼任)

業績

最近の主な論文

Sadhu K. K., Mizukami S., Yoshimura A. and Kikuchi K.
pH Induced dual "OFF-ON-OFF" switch: Influence of a suitably placed carboxylic acid.
Org. Biomol. Chem., 11, 563-568, 2013
Kikuta J., Wada Y., Kowada T., Sun-Wada G., Nishiyama I., Mizukami S., Maiya N., Yasuda H., Kumanogoh A., Kikuchi K., Germain R., and Ishii M.
Dynamic Visualization of RANKL and Th17-mediated Control of Osteoclast Function.
J. Clin. Invest., 123, 866-873, 2013
Baba R., Hori Y., Mizukami S. and Kikuchi K.
Development of a Fluorogenic Probe with a Transesterification Switch for Detection of Histone Deacetylase Activity.
J. Am. Chem. Soc., 134, 14310-14313, 2012
Mizukami S., Watanabe S., Akimoto Y. and Kikuchi K.
No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis.
J. Am. Chem. Soc., 134, 1623-1629, 2012
Hori Y., Nakaki K., Sato M., Mizukami S. and Kikuchi K.
Development of Protein Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association and No-wash Live-cell Imaging.
Angew. Chem. Int. Ed., 51, 5611-5614, 2012
Dhara K., Hori Y, Baba R. and Kikuchi K.
A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission.
Chem. Commun., 48, 11534-11536, 2012., 2012
Zeng Z., Mizukami S. and Kikuchi K.
Simple and Real-time Colorimetric Assay for Glycosidases Activity Using Functionalized Gold Nanoparticles and its Application for Inhibitor Screening.
Anal. Chem., 48, 11534-11536, 2012.
Matsushita H., Mizukami S., Mori Y., Sugihara F., Shirakawa M., Yoshioka Y. and Kikuchi K.
19F MRI monitoring of Gene Expression in Living Cells via Cell Surface β-Lactamase Activity.
ChemBioChem, 13, 1579-1583, 2012.
Okada S., Mizukami S. and Kikuchi K.
Switchable MRI Contrast Agents Based on Morphological Changes of pH-Responsive Polymers.
Bioorg. Med. Chem., 20, 769-774, 2012.
Sadhu K. K., Mizukami S., Lanam C. R. and Kikuchi K.
A new approach for fluorogenic protein labeling via photoinduced electron transfer based BL-tag protein labeling method.
Chem. Asian J., 7, 272-276, 2012.
Terai T., Ito H., Kikuchi K. and Nagano T.
Salicylic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes.
Chem. Eur. J., 18, 7377-7381, 2012.
Terai T., Kikuchi K., Urano Y., Kojima H. and Nagano T.
A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase(NAT) Activity of Cells.
Chem. Commun., 48, 2234-2236, 2012.
Kowada T., Kikuta J., Kubo A., Ishii M., Maeda H., Mizukami S. and Kikuchi K.
In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts.
J. Am. Chem. Soc., 133, 17772-17776, 2011.
Mizukami S., Yamamoto T., Yoshimura A., Watanabe S. and Kikuchi K.
Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging.
Angew. Chem. Int. Ed., 50, 8750-8752, 2011.
Watanabe S., Mizukami S., Akimoto Y., Hori Y. and Kikuchi K.
Intracellular Protein Labeling with Prodrug-Like Probes Based on Mutant β-Lactamase-Tag.
Chem. Eur. J., 17, 8342-8349, 2011.
Sadhu K. K., Mizukami S., Watanabe S. and Kikuchi K.
Sequential Ordering among Multicolor Fluorophores for Protein Labeling Facility Aggregation-Elimination Based β-Lactam Probes.
Mol. BioSyst., 7, 1766-1772, 2011.
Mizukami S., Matsushita H., Takikawa R., Sugihara F., Shirakawa M. and Kikuchi K.
19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression.
Chem. Sci., 2, 1151-1155, 2011.
Yoshimura A., Mizukami S., Hori Y., Watanabe S. and Kikuchi K.
Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant β-Lactamase-tag Technology.
ChemBioChem, 12, 1031-1034, 2011.
Hori Y., Egashira Y., Kamiura R. and Kikuchi K.
Noncovalent-interaction-promoted Ligation for Protein Labeling.
ChemBioChem.,11, 646-648, 2010.
Okada S., Mizukami S. and Kikuchi K.
Application of a Stimuli-responsive Polymer to the Development of Novel MRI Probes.
ChemBioChem., 11, 785-787, 2010.
Watanabe S., Mizukami S., Hori Y. and Kikuchi K.
Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology.
Bioconjug. Chem., 21, 2320-2326, 2010.
Sadhu K. K., Mizukami S., Watanabe S. and Kikuchi K.
Turn-on Fluorescent Switch Involving Aggregation and Elimination Processes for β-Lactamase-Tag.
Chem. Commun., 46, 7403-7405, 2010.
Mizukami S., Hosoda M., Satake T., Okada S., Hori Y., Furuta T. and Kikuchi K.
Photocontrolled Compound Release System Using Caged Antimicrobial Peptide.
J. Am. Chem. Soc., 132, 9524-9525, 2010.

受賞・表彰

2012
(財)井上科学振興財団 第29回井上学術賞
2008
Royal Society of Chemistry(英国王立化学協会)Emerging Investigator Award
2008
第22回日本IBM科学賞
受賞題目:「生体内分子を可視化する化学プローブのデザイン・合成・生物応用」
2004
(社)日本バイオイメージング学会 平成16年度研究奨励賞
2002
(財)富山県ひとづくり財団 平成14年度とやま賞
2002
(社)日本薬学会 平成14年度奨励賞
2001
(社)日本化学会生体機能関連化学部会 部会講演賞