Speakers (Oral Presentations)

Special Lecture

  •    Michael RETH
       (The University of Freiburg,
       Max Planck Institute of Immunobiology and Epigenetics, Germany)

  • Invited Speakers (in alphabetical order by surname)

    • Grégoire ALTAN-BONNET (Memorial Sloan-Kettering Cancer Center, USA)
    • Joji FUJISAKI (Columbia University, USA)
    • Thirumala-Devi KANNEGANTI (St. Jude Children's Research Hospital, USA)
    • Myung-Shik LEE (Sungkyunkwan University School of Medicine, Korea)
    • Kensuke MIYAKE (The University of Tokyo, Japan)
    • Stefan J. RIEDL (Sanford-Burnham Medical Research Institute, USA)
    • Erik M. SHAPIRO (Michigan State University, USA)
    • Mark S. SUNDRUD (The Scripps Research Institute, Florida, USA)

    Speakers from AKIRA Project and from IFReC
    (in alphabetical order by surname)

    • Shizuo AKIRA (Osaka University, Japan)
    • Cevayir COBAN (Osaka University, Japan)
    • Fuyuhiko INAGAKI (Hokkaido University, Japan) 
    • Masaru ISHII (Osaka University, Japan) 
    • Kazuya KIKUCHI (Osaka University, Japan) 
    • Kenta NAKAI (The University of Tokyo, Japan)
    • Nicholas I. SMITH (Osaka University, Japan)
    • Masahiro YAMAMOTO (Osaka University, Japan)

    Invited Speakers (Affiliation and Selected Publications)


    Michael RETH
    Professor. University of Freiburg / Max-Planck Institute of Immunobiology and Epigenetics, Germany

    Synthetic immune signaling. Schamel WW and Reth M. Curr Opin Biotechnol (2012)
    B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Winkelmann R. et al. Proc Natl Acad Sci USA (2011)
    Oligomeric organization of the B-cell antigen receptor on resting cells. Yang J. and Reth M. Nature (2010)


    Grégoire ALTAN-BONNET
    Lab head. Memorial Sloan-Kettering Cancer Center, U.S.A.

    Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. François P. et al. Proc Natl Acad Sci U S A. (2013)
    T cell responses to antigen: hasty proposals resolved through long engagements. Tkach K et al. Curr Opin Immunol. (2013)
    Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells. Cotari JW. et al. Sci Signal. (2013)


    Assistant professor. Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, Columbia University, U.S.A.

    Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Park D. et al. Cell Stem Cell (2012)
    In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Fujisaki J. et al. Nature (2011)


    Thirumala-Devi KANNEGANTI
    Associate member. St. Jude Children's Research Hospital, U.S.A.

    RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. Lukens JR. et al. Nature (2013)
    Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Lupfer C. et al. Nat Immunol. (2013)
    NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Anand PK. et al. Nature (2012)
    The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.Zaki MH. et al. Cancer Cell (2011)

    Lee picture.jpg

    Myung-Shik LEE
    Professor. Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea

    An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Shin NR. et al. Gut (2013)
    Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Kim KH. et al. Nat Med. (2013)
    Treatment of autoimmune diabetes in NOD mice by Toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition. Kim DH. et al. Diabetologia (2012)
    Inhibition of autoimmune diabetes by TLR2 tolerance. Kim KH. et al. J Immunol. (2011)


    Kensuke MIYAKE
    Professor. The Institute of Medical Science, The University of Tokyo, Japan

    An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Onji M. et al. Nat Commun. (2013)
    Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking. Fukui R. et al. Immunity (2011)
    Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. Fukui R. et al. J Exp Med. (2009)
    A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. Takahashi K. et al. J Exp Med. (2007)

    Riedl picture.jpg

    Stefan J. RIEDL
    Associate professor. Sanford-Burnham Medical Research Institute, U.S.A.

    The CARD plays a critical role in ASC foci formation and inflammasome signalling. Proell M. et al. Biochem J. (2013)
    NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Mace PD. et al. Nat Struct Mol Biol. (2011)
    The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Scott FL. et al. Nature (2009)


    Erik M. SHAPIRO
    Research director and Associate professor. Michigan State University, U.S.A.

    Serial monitoring of endogenous neuroblast migration by cellular MRI. Granot D. et al. Neuroimage (2011)
    In vivo detection of single cells by MRI. Shapiro EM. et al. Magn Reson Med. (2006)
    MRI detection of single particles for cellular imaging. Shapiro EM. et al. Proc Natl Acad Sci U S A. (2004)

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    Mark S. SUNDRUD
    Assistant professor. Department of Cancer Biology, The Scripps Research Institute, U.S.A.

    Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Keller TL. et al. Nat Chem Biol. (2012)
    Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells. Wan Q. et al. J Exp Med. (2011)
    Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Sundrud MS et al . Science (2009)

    Speakers from AKIRA Project and from IFReC
    (Click on a speaker's picture for more information)

    Akira_picture.jpg Coban picture.jpg Inagaki_picture.jpg Ishii_picture.jpg Kikuchi_picture.jpg Nakai_picture.jpg

    Smith_picture.jpg Yamamoto_picutre.jpg